How does Histamine intolerance develop?
When our body is functioning optimally, Histamine is broken down by an enzyme called diamine oxidase (doa) in our digestive tract. The activity of this enzyme can be downregulated by certain medications, gastrointestinal inflammation, leaky gut, SIBO, foods containing Histamine like compounds such as those mentioned above, and genetics in some people.
When this happens and Histamine isn’t broken down properly, a build-up occurs in the bloodstream. Because it travels via the bloodstream, it can travel anywhere in the body and affect any organ it reaches. This fact makes histamine intolerance very difficult to pinpoint, as the symptoms vary significantly from person to person depending on which organs or body systems are most heavily affected. Some of the more common symptoms of histamine intolerance include: